Cancer care specialists at BBG providing targeted therapy hold advanced qualifications in oncology, often with specialised training in breast cancer treatment. We possess extensive expertise in molecular profiling, precision medicine, and the latest advancements in targeted therapies, ensuring you’ll receive individualised and cutting-edge care tailored to your unique cancer characteristics.
Treatments - Oncology
Targeted Therapy For Breast Cancer
Targeted therapy for breast cancer involves using drugs or other substances to precisely identify and attack cancer cells while minimising harm to normal cells. This approach targets specific molecular changes that are unique to cancer cells, such as genetic mutations or protein overexpression. By interfering with cancer cell growth and survival pathways, targeted therapies can slow or stop tumour growth, shrink tumours, or prevent cancer from spreading. These treatments often result in fewer side effects compared to traditional chemotherapy, offering patients a more tailored and effective approach to cancer treatment with the potential for improved outcomes and quality of life.
At a Glance
Anti-HER2 therapy for breast cancer
One of the key targeted therapies utilised by BBG is anti-HER2 therapy. HER2 (human epidermal growth factor receptor 2) is a protein that promotes the growth of cancer cells.
Approximately 20-25% of breast cancers overexpress HER2, making it a critical target for treatment. Medications such as trastuzumab (HerceptinTM), pertuzumab (PerjetaTM), and ado-trastuzumab emtansine (KadcylaTM) specifically target HER2-positive breast cancer cells, inhibiting their growth and proliferation.
How does targeted therapy for breast cancer work?
Trastuzumab is a monoclonal antibody that binds to the HER2 protein on the surface of cancer cells, blocking its signalling pathways and stimulating the immune system to attack the cancer cells. Pertuzumab works in conjunction with trastuzumab by targeting a different part of the HER2 protein, thereby enhancing the blockade of HER2 signalling. Ado-trastuzumab emtansine is an antibody-drug conjugate that delivers a potent chemotherapy drug directly to HER2-positive cancer cells, minimising systemic toxicity.
Types of targeted therapies for breast cancer
In addition to anti-HER2 therapy, BBG may utilise other targeted agents based on the molecular characteristics of your tumour. For example, hormone receptor-positive breast cancers may be treated with endocrine therapy, which targets the oestrogen receptor (ER) or progesterone receptor (PR) to block the effects of oestrogen or progesterone on cancer cell growth. Common endocrine therapies include selective oestrogen receptor modulators (SERMs) such as tamoxifen, aromatase inhibitors (AIs) like letrozole or anastrozole, and selective oestrogen receptor degraders (SERDs) such as fulvestrant.
For advanced or metastatic breast cancer, targeted therapies may also include inhibitors of specific signalling pathways involved in cancer growth and survival. For example, inhibitors of the PI3K/AKT/mTOR pathway, such as everolimus, may be used in combination with endocrine therapy for hormone receptor-positive, HER2-negative breast cancer that has become resistant to standard treatments.
Targeted therapy for breast cancer in Birmingham
BBG’s approach to targeted therapy goes beyond just treating the cancer itself; it encompasses a holistic approach to patient care that addresses the physical, emotional, and psychosocial aspects of living with breast cancer. The multidisciplinary team at BBG works collaboratively to tailor treatment plans to each patient’s unique needs, preferences, and goals, with the overarching aim of improving overall well-being and quality of life.
In addition to medical interventions, BBG places a strong emphasis on supportive care services to help you manage the physical and emotional challenges of breast cancer treatment. This may include access to oncology nurses, nurse navigators, dietitians, physical therapists, social workers, and counsellors who provide education, guidance, and emotional support throughout the treatment journey.
Furthermore, BBG recognises the importance of patient empowerment and education in promoting well-being. You will be actively involved in decision-making regarding your treatment options, and comprehensive information about the risks, benefits, and potential side effects of targeted therapies is provided to help you make informed choices about your care. Importantly, BBG’s commitment to improving well-being extends beyond the duration of active treatment. Long-term survivorship care plans are developed to support you in transitioning from active treatment to post-treatment survivorship, addressing issues such as surveillance for recurrence, management of treatment-related side effects, lifestyle modifications, and psychosocial support.
Overall, targeted therapy at the Birmingham Breast Group represents a cutting-edge approach to breast cancer treatment that combines scientific advancements with compassionate, patient-centred care. By harnessing the power of precision medicine, BBG strives to optimise outcomes and enhance your well-being when affected by breast cancer, empowering you to live your life to the fullest.
Frequently Asked Questions About Targeted Therapy
Good candidates for targeted therapy at BBG include those with specific molecular characteristics in their breast cancer, such as HER2 overexpression or hormone receptor positivity. If conventional treatments have failed or you have advanced or metastatic breast cancer, you may also benefit from targeted therapy interventions tailored to your tumour biology.
Side effects of targeted therapy medications may vary depending on the specific drug used and individual factors. Common side effects may include nausea, diarrhoea, fatigue, skin rash, and risk of infection. However, targeted therapies generally cause fewer side effects compared to traditional chemotherapy.
The length of a typical targeted therapy treatment course at BBG varies depending on the specific cancer type, stage, and individual response to treatment. Treatment durations may range from several weeks to months or longer, with regular monitoring and adjustments made based on treatment efficacy and tolerability.
How much does Targeted therapy cost in Birmingham?
As each case is unique, the cost of treatment at BBG may vary depending on individual factors. We tailor our approach to meet your specific needs, ensuring that you receive personalised care and comprehensive support throughout your journey.
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Targeted Therapy For Breast Cancer
Our Specialist Team
Meet the dedicated professionals at Birmingham Breast Group – committed to excellence, compassion, and personalised care for every patient.
Written by a patient at BMI The Priory Hospital, 17th August 2020
Mr Henderson was kind and understanding and I felt completely at ease with him. He was well informed of my condition and explained his treatment plan to me fully. He has been very attentive in answering emails from me and I really cannot recommend him highly enough. I feel very fortunate to have been in his care.
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